setback

/ˈsɛtˌbæk/

an unfortunate happening that hinders or impedes; something that is thwarting or frustrating

Chinese meaning: 挫折；阻碍

The project suffered a major setback when funding was withdrawn.

当资金被撤回时，该项目遭受了重大挫折。

Despite the setback, the team remained determined to continue.

尽管遭遇挫折，团队仍然决心继续。